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目的探讨无创正压通气对慢性阻塞性肺病急性发作期的临床疗效,及对血气的影响。方法将大庆油田总医院呼吸科2009-01-2010-01 56例慢性阻塞性肺病急性发作期合并2型呼衰患者,随机分为观察组和对照组各28例,两组均给予常规药物治疗,观察组在常规药物治疗的基础上同时给予无创正压通气,观察两组疗效。结果观察组与对照组治疗后与治疗前比较,pH值升高,PaCO2下降,PaO2上升,差异均有统计学意义(P<0.05),与对照组比较,观察组心率(HR)、呼吸频率(RR)较对照组明显改善(P<0.05);观察组血气改善时间明显缩短,且观察组住院时间明显短于对照组,P<0.01。结论无创正压通气治疗慢性阻塞性肺病急性发作期合并2型呼衰疗效确切,可以明显改善呼吸功能,提高PaO2,降低PaCO2。
Objective To investigate the clinical effect of non-invasive positive pressure ventilation on acute exacerbation of chronic obstructive pulmonary disease (COPD) and its influence on blood gas. Methods A total of 56 patients with chronic obstructive pulmonary disease (COPD) complicated with type 2 respiratory failure were randomly divided into observation group (28 cases) and control group (28 cases). Both groups were given conventional drug treatment . The observation group received noninvasive positive pressure ventilation on the basis of routine drug treatment. The curative effect of the two groups was observed. Results Compared with the control group before and after treatment, the values of PaCO2, PaO2 and PaO2 in the observation group and the control group were significantly different (P <0.05). Compared with the control group, the changes of heart rate (HR), respiratory rate (RR) was significantly improved compared with the control group (P <0.05). The improvement time of blood gas in the observation group was significantly shortened, and the length of stay in the observation group was significantly shorter than that of the control group (P <0.01). Conclusion Noninvasive positive pressure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease with type 2 respiratory failure is effective and can significantly improve respiratory function, increase PaO2 and decrease PaCO2.