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目的探讨生长分化因子-15(GDF-15)血清水平与急性心肌梗死(AMI)的相关性,为AMI的预后评价提供研究依据。方法选取2013年9月至2015年1月在承德市中心医院心血管内科诊断为AMI(AMI组)和非冠心病(NCHD,NCHD组)的汉族患者,共计192例,收集临床资料,测定生化指标及GDF-15血清水平。结果与NCHD组比较,AMI组患者年龄、吸烟、血糖(Glu)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平差异均有统计学意义(P<0.05);AMI组GDF-15血清水平明显高于NCHD组(P<0.01);AMI组GDF-15血清水平与Glu、TC、LDL-C、hs-CRP呈强正相关性。结论 GDF-15水平的升高与AMI有明显相关性,GDF-15可作为一种心肌梗死监测指标。
Objective To investigate the correlation between serum levels of GDF-15 and acute myocardial infarction (AMI) and provide the basis for the prognosis evaluation of AMI. Methods A total of 192 Chinese Han patients diagnosed as AMI (AMI group) and non-CHD (NCHD group) at Department of Cardiology, Chengde Central Hospital from September 2013 to January 2015 were enrolled in this study. Clinical data were collected and biochemical Indicators and GDF-15 serum levels. Results Compared with NCHD group, there were significant differences in age, smoking, Glu, TC, TG and LDL-C in AMI patients (P <0.05). The serum level of GDF-15 in AMI group was significantly higher than that in NCHD group (P <0.01). The serum level of GDF-15 in AMI group was positively correlated with Glu, TC, LDL-C and hs-CRP. Conclusion The increase of GDF-15 level has a significant correlation with AMI, and GDF-15 can be used as a monitoring indicator of myocardial infarction.