作者对122例癫痫女患者136次妊娠作了前瞻性研究。如患者总的癫痫发作少于3次、发作次数的资料不完全或妊娠以流产结束者均被排除在这项研究之外。对研究的患者通常每月作一次神经病学的估价,记录癫痫发作的病史,检查临床应用药物的毒性,注意诱发癫痫发作的因素,询问患者是否有规律地服用每日药量。通过睡眠剥夺(指患者比平素睡眠开始延迟2小时以上)来诱发癫痫发作。测定抗痫药物的血浆浓度。86例(占63%)患者用一种抗痫药物治疗,25例患者用二种,2例患者用三种药物治疗。23例患者未用药物。患者分娩时的平均年龄为25±4岁,癫痫的病期平均13.7±6年。其中大发作60例、局 The authors prospectively studied 136 pregnancies in 122 women with epilepsy. Patients with less than 3 seizures, incomplete episodes, or termination of pregnancy with abortion were excluded from the study. Patients are usually assessed for neurology on a monthly basis, the history of seizures is recorded, the toxicity of clinically applied drugs is examined, the factors that trigger seizures are noted, and the patient is asked if they regularly take daily doses. Seizures are induced by sleep deprivation, which refers to patients being delayed by more than 2 hours from the onset of sleep. Determination of anti-epileptic drug plasma concentration. Eighty-six (63%) patients were treated with one antiepileptic drug, two with 25 patients and three with two patients. 23 patients without medication. The mean age at delivery was 25 ± 4 years and the duration of epilepsy was 13.7 ± 6 years. One of the major episodes of 60 cases, Bureau