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目的 :探讨后腹腔镜下肾部分切除术联合过继免疫疗法应用于肾癌的疗效。方法 :选取我院收治的90例后腹腔镜肾部分切除术后病理确诊为肾透明细胞癌患者,将其随机分为观察组和对照组,观察组接受术后常规治疗联合过继免疫治疗,对照组术后接受常规治疗联合细胞因子治疗,比较两组治疗前后的免疫指标、临床指标变化。结果 :治疗前两组患者的白细胞、转氨酶、尿素氮以及肌酐水平比较无明显差异,治疗后对照组的白细胞较治疗前明显升高,转氨酶明显下降,且与观察组比较有明显差异。治疗前两组患者的CD3+、CD4+、CD8+、CD4+/CD8+、NK指标比较无明显差异,治疗后观察组的CD3+、CD4+、CD4+/CD8+、NK与治疗前相比均明显升高,与对照组相比有明显差异。结论 :腹腔镜肾部分切除术后采用过继免疫疗法治疗能够有效提高治疗效果,增强机体免疫功能,且不良反应较小,值得推广应用。
Objective: To investigate the effect of retroperitoneal partial nephrectomy combined with adoptive immunotherapy on renal cell carcinoma. Methods: Ninety cases of retroperitoneal laparoscopic partial nephrectomy in our hospital were selected as pathologically confirmed patients with clear cell renal cell carcinoma. They were randomly divided into observation group and control group. The observation group received routine postoperative combined with adoptive immunotherapy, Group received conventional therapy combined with cytokines postoperative treatment, immune indicators before and after treatment were compared, clinical changes. Results: The levels of leukocyte, aminotransferase, urea nitrogen and creatinine were not significantly different between the two groups before treatment. After treatment, the leukocytes in the control group were significantly higher than those before treatment, and the levels of aminotransferases were significantly decreased. There was significant difference between the two groups. The levels of CD3 +, CD4 +, CD8 +, CD4 + / CD8 + and NK in the two groups before treatment were not significantly different. After treatment, the levels of CD3 +, CD4 +, CD4 + / CD8 + and NK in the observation group were significantly higher than those in the control group Compared with significant differences. Conclusion: Laparoscopic partial nephrectomy with adoptive immunotherapy can effectively improve the therapeutic effect, enhance immune function, and adverse reactions are small, it is worth popularizing and applying.