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目的：探讨盐酸屈他维林防治前列腺切除术后膀胱痉挛的临床疗效。方法将经尿道前列腺等离子体切除术和耻骨上前列腺摘除术102例随机分成两组，各51例，分别为A组（盐酸屈他维林组）和B组（硬膜外自控镇痛泵组）。术后A组给盐酸屈他维林80mg，肌肉注射，q12h，肛门排气后改为口服，共3d。B组给布比卡因留管镇痛，72h后撤除。分别记录两组膀胱痉挛发生例数和次数。结果A组6例19次和B组8例10次。经统计学处理，无差异。结论盐酸屈他维林防治前列腺手术后膀胱痉挛的临床疗效肯定，不良反应轻微，值得临床推广使用。“,”Objective To investigate the clinical effect of Drotaverine hydrochloride in the prevention of bladder spasm after prostatectomy. Methods Total of 102 patients who underwent PKRP and suprapubic prostatectomy were divided into Group A ( Drotaverine hydrochloride group) and Group B ( patient-controlled epidural analgesic group) , each group of 51 cases. Patients in Group A were adminstrated with 80mg Drotaverine hydrochloride, intramuscular injection, Q12h, anal exhaust, and then they were taken orally, a total of three days. Patients in Group B were treated with bupivacaine analgesia to relieve the pain, 72h later, the tube was removed. Bladder spasm cases and frequence in two groups were recorded. Results There were 19 times bladder spasm in 6 cases of Group A, and 10 times in 8 cases of Group B. No significant difference was found in bladder spasm cases and frequence. Conclusion Clinical efficacy of Drotaverine Hydrochloride in prevention of bladder spasm after operation was better and merited to be applied in clinic.