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目的 :研究血管紧张素转换酶 (ACE)基因多态性与 2型糖尿病并发高血压的关系。方法 :应用 PCR方法分析 149例 2型糖尿病患者及正常对照者的 ACE基因型。结果 :1ACE基因型及等位基因构成比 ,正常对照组与 2型糖尿病组无显著性差异 ;2并发高血压组 DD型及 D等位基因频率显著高于无高血压组 (P <0 .0 5 )。结论 :ACE基因 I/ D多态性与 2型糖尿病并发高血压有关。
Objective: To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and type 2 diabetes with hypertension. Methods: ACE genotypes were analyzed by PCR in 149 patients with type 2 diabetes mellitus and controls. Results: The genotypes and alleles of 1ACE showed no significant difference between normal control group and type 2 diabetes mellitus group. 2 The frequencies of DD and D allele in hypertensive patients with hypertension were significantly higher than those without hypertension (P <0.05). 0 5). Conclusion: ACE gene I / D polymorphism is associated with type 2 diabetes complicated with hypertension.