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采用幼年ＳＤ雄性大鼠３０只，体重１５０±２０ｇ，随机分成三组，每组１０只：（１）基础饲料组：普通大鼠饲料；（２）猪油组：基础饲料中加入１０％猪油和１．５％胆固醇；（３）玉米油组：在基础饲料中加入１０％玉米油和１．５％胆固醇，饲养９周，比较玉米油和猪油对大鼠血脂血糖和脑脂褐质的不同影响。结果表明，玉米油组ＴＣ和ＬＤＬ－Ｃ水平较猪油组低，虽然两组均高于基础饲料组。玉米油组的ＨＤＬ－Ｃ比猪油升高不显著，但ＨＤＬ－Ｃ／ＴＣ（％）增加，同时ＬＤＬ－Ｃ／ＨＤＬ－Ｃ比值下降。基础饲料组，猪油组和玉米油组的大鼠平均血清ＴＧ分别为１.２８，１.２１和１.４５（ｍｍｏｌ／Ｌ），各组之间的差别不显著。高脂饲料组动物的空腹血糖（ＳＧ）较基础饲料组高，但差别无统计学意义。三组不同饲料大鼠的脑脂褐质（ＬＰＦ）含量测定结果显示:基础饲料组大鼠的ＬＰＦ平均值１２.９Ｕ／ｇ蛋白质，而玉米油组和猪油组均明显升高，分别为２８.３和２８.８Ｕ／ｇ蛋白质。在以血脂各项指标为自常量，大脑ＬＰＦ含量为因变量的相关分析中发现，ＬＰＦ与ＴＣ和ＬＤＬ－Ｃ呈正相关，相关系数分别为０.６９１和０.５４７，Ｐ＜０.０１．
Thirty male SD rats aged 150 ± 20g were randomly divided into three groups with 10 rats in each group: (1) basal diet group: normal rat diet; (2) lard group: 10% pigs Oil and 1.5% cholesterol. (3) Corn oil group: 10% corn oil and 1.5% cholesterol were added into the basic feed and fed for 9 weeks. The effects of corn oil and lard on the blood glucose, Different effects of quality. The results showed that the levels of TC and LDL-C in corn oil group were lower than those in lard oil group, although the two groups were higher than the basic feed group. HDL-C in corn oil group was not significantly higher than that in lard oil, but the HDL-C / TC (%) increased and the ratio of LDL-C / HDL-C decreased. The average serum TG of rats in the basal diet, lard and corn oil groups was 1.28, 1.21 and 1.45 (mmol / L), respectively, with no significant difference among the groups. The fasting blood glucose (SG) of high-fat diet group was higher than that of the basic diet group, but the difference was not statistically significant. The results of LPF assay in three groups of fed rats showed that the LPF of the rats in the basal diet group averaged 12.9 U / g protein, while those in the corn oil group and lard oil group were significantly 28.3 and 28.8 U / g protein. Correlation analysis showed that there was a positive correlation between LPF and TC and LDL-C with correlation coefficient of 0.691 and 0.547 respectively (P <0.01).