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目的就丹参片与华法林在国际标准化比值(INR)中的结果进行比对。方法选取南京中医药大学附属南京市中西医结合医院2011年6月至2013年6月所收治的100例非瓣膜病房颤患者,基于随机数字法将其分为2组,分别是丹参片组(50例)和华法林组(50例),丹参片组服用丹参片,华法林组服用华法林片,服药后第7、14天抽取静脉血测定血凝指标INR。结果与华法林组相比,丹参片组的血凝指标INR变化速度较快,存在着较为明显的差异,具有统计学意义(P<0.05)。两组患者的出血并发症发生率差异无统计学意义(P>0.05)。结论丹参片的血凝指标INR变化速度较快,安全有效,不良反应少,是一种较佳的辅助治疗药物,值得推广应用。
Objective To compare the results of Danshen Tablets with warfarin in International Normalized Ratio (INR). Methods A total of 100 non-valvular atrial fibrillation patients admitted to Nanjing Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine from June 2011 to June 2013 were divided into two groups according to the random number method: (50 cases) and warfarin group (50 cases). The Danshen Tablet group took Danshen tablets, the warfarin group took warfarin tablets, and the venous blood samples were taken for determination of INR on the 7th and 14th day after the medication. Results Compared with warfarin group, the rate of change of INR in Danshen Tablets group was faster than that of warfarin group, with significant difference (P <0.05). There was no significant difference in the incidence of bleeding complications between the two groups (P> 0.05). Conclusion The hemagglutination index of Salvia miltiorrhiza tablets is a kind of better adjuvant therapy because of rapid change of INR, safe and effective, less adverse reactions. It is worth to be popularized and applied.