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目的调查北京地区肺炎链球菌对青霉素等抗生素的耐药率。方法用Ｅｔｅｓｔ及琼脂稀释法测定临床分离的７９株肺炎链球菌１５种抗生素的最低抑制浓度（ＭＩＣ）。结果Ｅｔｅｓｔ测得１０株（１２．７％）低耐青霉素（ＭＩＣ０．１２５～１μｇ／ｍｌ），１株（１．３％）高耐青霉素（ＭＩＣ４μｇ／ｍｌ）；仅１株处于头孢曲松、头孢噻肟中介范围（ＭＩＣ１μｇ／ｍｌ）．琼脂稀释法测得阿莫西林、阿莫西林／棒酸、头孢呋肟、环丙沙星、氯霉素、四环素、红霉素的耐药率分别为１．３％、１．３％、２．５％、２．５％、１６．５％、４９．４％、４０．５％，所有菌株对头孢曲松、万古霉素敏感。结论北京地区１４％的肺炎链球菌耐青霉素，耐三代头孢菌素及多重耐药株罕见。
Objective To investigate the resistance rate of Streptococcus pneumoniae to penicillin and other antibiotics in Beijing. Methods The minimum inhibitory concentrations (MICs) of 15 clinically isolated 79 Streptococcus pneumoniae antibiotics were determined by Etest and agar dilution method. Results Etest showed that 10 strains (12.7%) were resistant to penicillin (MIC0.125-1μg / ml) and 1 strain (1.3%) were resistant to penicillin (MIC4μg / ml). Only 1 strain was in ceftriaxone, Cefotaxime intermediate range (MIC1μg / ml). The resistance rates of amoxicillin, amoxicillin / clavulanic acid, cefuroxime, ciprofloxacin, chloramphenicol, tetracycline and erythromycin were 1.3%, 1.3% 2.5%, 2.5%, 16.5%, 49.4%, 40.5%. All strains were sensitive to ceftriaxone and vancomycin. Conclusions 14% of Streptococcus pneumoniae in Beijing are resistant to penicillin, third-generation cephalosporins and multi-drug resistant strains.