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白细胞介素6(IL-6)在免疫系统中具有多效性和多功能性。IL-6主要由巨噬细胞产生,通过去除传染性病原体、诱导受损组织愈合、急性期免疫反应以及凝血级联反应从而执行保护功能。IL-6的表达调控严格遵循转录机制,但转录后机制失调后,持续产生的IL-6在自身免疫性疾病和慢性炎症中有重要作用。近年来,用人源化的抗IL-6受体抗体阻断IL-6能对疾病的治疗产生明显疗效,相关的分子靶向制剂也正在研究中。
Interleukin 6 (IL-6) is pleiotropic and versatile in the immune system. IL-6 is produced primarily by macrophages and performs protective functions by removing infectious pathogens, inducing healing of damaged tissues, the acute immune response, and the coagulation cascade. The regulation of IL-6 expression strictly follows the transcriptional mechanism, but after the post-transcriptional mechanism is disrupted, the persistent production of IL-6 plays an important role in autoimmune diseases and chronic inflammation. In recent years, the use of humanized anti-IL-6 receptor antibodies blocking IL-6 can have a significant effect on the treatment of diseases, and relevant molecular targeted preparations are also under study.