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目的本研究通过进行氨氯地平联合阿托伐他汀治疗高血压合并冠心病的临床观察,以期为治疗方案的制定提供依据。方法将2013年1月至2015年5月本院收治的112例高血压合并冠心病患者纳入试验对象。按照随机对照的原则将所有患者分成观察组以及对照组,每组均56例。对照组患者仅给予氨氯地平进行治疗,观察组患者在对照组的基础上联合阿托伐他汀进行治疗,疗程为8周。治疗结束后,比较两组患者治疗前后的血压、血脂水平以及心绞痛改善情况,并注意观察不良反应的发生情况。结果治疗结束后,两组患者的血压、血脂水平以及心绞痛症状均较治疗前明显好转;观察组患者治疗后的血压、血脂水平以及心绞痛改善情况明显优于对照组;两组患者治疗期间的不良反应发生情况无明显差异。结论采用氨氯地平联合阿托伐他汀治疗高血压合并冠心病,具有较好的降压疗效,还能够显著降低血脂水平、缓解心绞痛症状,且药物安全性好,可以在临床上推广应用。
Objective To study the clinical efficacy of amlodipine and atorvastatin in the treatment of patients with hypertension and coronary heart disease. Methods From January 2013 to May 2015, 112 patients with hypertension complicated with coronary heart disease admitted to our hospital were enrolled in the study. According to the principle of randomized control, all patients were divided into observation group and control group, 56 cases in each group. Patients in the control group were treated with amlodipine only. The patients in the observation group were treated with atorvastatin on the basis of the control group for 8 weeks. After treatment, blood pressure, blood lipid and angina pectoris in both groups were compared before and after treatment, and the occurrence of adverse reactions was observed. Results After treatment, blood pressure, blood lipid and angina pectoris in both groups were significantly improved compared with those before treatment. The improvement of blood pressure, blood lipid and angina pectoris in observation group was better than that in control group. No significant difference in response occurred. Conclusion Combination of amlodipine and atorvastatin in patients with hypertension and coronary heart disease has better antihypertensive effect, but also can significantly reduce blood lipid levels, relieve angina pectoris, and the drug is safe and can be widely applied in clinic.