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对抗破伤风毒素人源单克隆抗体G2、G6、G2 +G6与精制破伤风抗毒素进行了中和效力比较试验。结果表明 ,G2、G6二株单抗的中和毒力活性均比精制破伤风抗毒素的高。G2和G6混合后呈完全中和。表明这些人源单抗在中和毒力方面能够取代精制破伤风抗毒素 ,可满足临床试验需求。
The anti-tetanus toxin human monoclonal antibodies G2, G6, G2 + G6 and purified tetanus antitoxin were neutralized efficacy comparison test. The results showed that the neutralizing virulence activity of the two monoclonal antibodies to G2 and G6 was higher than that of the purified tetanus antitoxin. G2 and G6 mixed completely neutralized. This indicates that these human monoclonal antibodies can replace the purified tetanus antitoxin in terms of neutralization and virulence to meet the needs of clinical trials.