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目的：比较丙戊酸镁与苯噻啶对偏头痛的疗效。方法：偏头痛病人６９例，分为丙戊酸镁组４１例（男性１８例，女性２３例，年龄３４±ｓ８ａ），用丙戊酸镁０．２～０．４ｇ，ｐｏ，ｂｉｄ或ｔｉｄ；苯噻啶组２８例（男性１２例，女性１６例，年龄３３±１１ａ），用苯噻啶０．５～１．０ｍｇ，ｐｏ，ｔｉｄ，疗程均为１２ｗｋ。结果：２组总有效率差别不显著（Ｐ＞０．０５），但２组基本控制率差别非常显著（Ｐ＜０．０１）。２组不良反应均较轻微，无１例终止治疗。结论：丙戊酸镁对偏头痛的基本控制率优于苯噻啶，是一种有效的治疗偏头痛的药物
Objective: To compare the efficacy of magnesium valproate and phenylthiazide on migraine. Methods: A total of 69 migraine patients were divided into magnesium valproate group, 41 cases (18 males and 23 females, age 34 ± s8a). The patients were treated with 0.2-0.4 g magnesium valproate, po, bid or tid ; PZT group 28 cases (12 males and 16 females, age 33 ± 11a) with PZT 0.5 ~ 1.0mg, po, tid, the course of treatment were 12wk. Results: There was no significant difference in total effective rate between the two groups (P> 0.05), but the difference between the two groups was significant (P <0.01). Two groups of adverse reactions were minor, no one termination of treatment. CONCLUSION: Magnesium valproate is superior to phenylthiazide for the basic control of migraine and is an effective drug for migraine