目的 :建立硝酸异山梨酯滴丸溶出度的测定条件和检测方法。方法 :稀盐酸 ( 9→ 10 0 0 )为溶出介质 ,用HPLC法测定硝酸异山梨酯滴丸含量。结果 :线性范围 ( 8.2～ 41.0 ) μg·ml-1;平均回收率为 99.9% ,RSD为 1.2 %。结论 :本法能考察和控制硝酸异山梨酯滴丸的质量 Objective: To establish the determination conditions and detection methods of isosorbide dinitrate dropping pills. Methods: Dilute hydrochloric acid (9 → 100) was used as dissolution medium. The content of isosorbide dinitrate dropping pills was determined by HPLC. Results: The linear range (8.2 ~ 41.0) μg · ml-1; the average recovery was 99.9% with a RSD of 1.2%. Conclusion: This method is capable of investigating and controlling the quality of isosorbide dinitrate dropping pills