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目的:观察仙鱼汤配合紫杉醇加顺铂即TP方案治疗Ⅲb及Ⅳ期非小细胞肺癌(NSCLC)的临床疗效。方法:将60例符合临床试验要求的Ⅲb及Ⅳ期NSCLC患者按照自愿原则分为3组各20例。仙鱼汤组予仙鱼汤治疗;化疗组予TP方案治疗;联合组予仙鱼汤加TP方案治疗。21天为1周期,连用2周期为1疗程。治疗1疗程后进行临床疗效评价。结果:①在抑制瘤体方面,仙鱼汤组、化疗组稳定率均低于联合组,但3组间两两比较,差异均无显著性意义(P>0.05)。②仙鱼汤组、联合组分别与化疗组比较,能明显改善咳嗽、乏力、纳差等临床症状,差异均有非常显著性意义(P<0.01)。③联合组、仙鱼汤组患者的Karnofsky评分均有提高,分别与化疗组比较,差异均有非常显著性意义(P<0.01)。结论:仙鱼汤配合TP方案治疗Ⅲb及Ⅳ期NSCLC能够明显改善患者临床症状,提高生存质量,有助于按规定完成化疗周期。
Objective: To observe the clinical efficacy of Xianyu Decoction combined with paclitaxel and cisplatin, TP regimen in the treatment of stage Ⅲb and Ⅳ non-small cell lung cancer (NSCLC). Methods: Sixty patients with stage Ⅲb and Ⅳ NSCLC who met the clinical trial were divided into 3 groups of 20 patients according to the principle of voluntariness. Angelfish soup group Angelica soup treatment; chemotherapy group to TP regimen; combination group Angelfish Tonga TP regimen. 21 days for a cycle, once every 2 cycles for a course of treatment. After treatment for 1 course of clinical efficacy evaluation. Results: ①In the inhibition of tumor, the stability of Xian Yu Tang and chemotherapy group were lower than that of the combined group, but there was no significant difference between the three groups (P> 0.05). (2) The Xian Yu Decoction group and the combined group were able to significantly improve the clinical symptoms such as cough, fatigue and anorexia compared with the chemotherapy group, the difference was significant (P <0.01). (3) The Karnofsky scores of patients in combination group and Xianyu Decoction group were significantly higher than those in chemotherapy group (P <0.01). Conclusion: Xian-yi decoction combined with TP regimen in the treatment of stage Ⅲb and Ⅳ NSCLC can significantly improve the clinical symptoms and improve the quality of life, and help to complete the cycle of chemotherapy.