控释美托洛尔制剂(美托洛尔CR/ZOK和OROS)每日服用一次,可维持24h用药间隔期间衡定的血药浓度,避免出现峰浓度,且具有效的抗高血压、心绞痛作用。用于治疗轻、中度高血压,疗效优于其普通型、基质缓释剂、普通型阿替洛尔或比索洛尔。抗心绞痛作用与分次应用普通型美托洛尔或阿替洛尔相似。控释美托洛尔耐受性好,副作用小,因具有β_1受体选择性,故对支气管的β_2受体作用较其它β受体阻滞剂弱。 Controlled-release metoprolol formulations (Metoprolol CR / ZOK and OROS) are taken daily to maintain a constant plasma concentration over a 24-hour interval to avoid peak concentrations and to be effective against hypertension, angina effect. For the treatment of mild to moderate hypertension, its efficacy is superior to its ordinary type, matrix sustained-release agent, common type of atenolol or bisoprolol. Anti-angina pectoris and sub-divided use of ordinary metoprolol or atenolol similar. Controlled release metoprolol is well tolerated and has few side effects. Because of its β 1 receptor selectivity, β 2 -receptor in the bronchial tube is weaker than other β-blockers.