一、前言超氧化物歧化酶(Superoxide Dismutase,SOD)是一类清除含氧自由基的金属酶。它广泛存在于各种生物体内。自二十多年前Mc Cord和Fridovich首次从牛血中提纯出CuZn-SOD并首次在医学中应用,至目前为止,SOD除用作抗炎药物外,还具有抗衰老、抗肿瘤和抗辐射作用。广大医学科学工作者越来越重视其结构、功能及其在医学中应用的研究。二、生物体内的抗氧化防御体系在需氧生物中,机体所摄取的氧基本是作为呼吸链的终末受体,被细胞色素C氧化酶催化还原成水,同时偶联ADP的磷酸化 I. INTRODUCTION Superoxide dismutase (SOD) is a type of metalloenzyme that scavenges oxygen free radicals. It is widespread in a variety of organisms. For the first time in medicine, Mc Cord and Fridovich purify CuZn-SOD from bovine blood more than 20 years ago. Until now, SOD has anti-aging, anti-tumor and anti-radiation effects effect. The majority of medical science workers pay more and more attention to its structure, function and its application in medicine. Second, the body’s antioxidant defense system In aerobic organisms, the body’s intake of oxygen is basically as the respiratory chain of the terminal receptor, was catalyzed by cytochrome C oxidase into water, coupled with the phosphorylation of ADP