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以一定重力致家兔侧股骨中下1／3处粉碎性骨折造成创伤性休克模型，连续监测血压4h．采用薄层层析及无机磷定量法测定肺表面活性物质（PS）的主要功能成分磷脂酰胆碱（PC）和总磷脂（TPL）含量．观察到创伤后4h末．血压及肺组织匀浆PC含量明显低于生理盐水（NS）对照组（P＜0．01），TPL含量亦降低，但不如PC显著（P＜0．05）．创伤前给予山莨菪碱(654—2），能防止血压降低和PS减少．结果提示，PS减少是创伤性休克时重要的病理生理变化；654—2能减轻或在一定程度上防止休克的发生和发展．
To a certain degree of gravity caused by the rabbit side of the femur in 1/3 of comminuted fractures caused by traumatic shock model, continuous monitoring of blood pressure 4h. The contents of phosphatidylcholine (PC) and total phospholipid (TPL), the main functional components of pulmonary surfactant (PS), were determined by thin-layer chromatography and inorganic phosphorus quantification. 4h after trauma was observed. The content of PC in blood pressure and lung homogenate was significantly lower than that in NS group (P <0.01), and the content of TPL was also lower than that in PC group (P <0.05). Anisodamine (654-2) given before the trauma prevented a decrease in blood pressure and PS. The results suggest that PS reduction is an important pathophysiological change in traumatic shock; 654-2 can reduce or to a certain extent prevent the occurrence and development of shock.