恶性肿瘤与止血异常、肿瘤细胞增殖与转移,一方面受血管内皮细胞、血小板、凝血系统和纤维蛋白溶解系统的影响;另一方面肿瘤细胞产生的前凝血质、前纤维蛋白溶酶原激活物,对止血机制亦有影响.一、肿瘤细胞的凝血、纤维蛋白溶解作用1.致活第五因子.Gordon 等观察到,在人与动物的恶性肿瘤组织内,除能分离出组织凝血激酶样物质外,尚存在第五因子致活物和蛋白酶.肿瘤细胞可直接激活第五因子.他们并研究了V_2 家兔肿瘤前凝血 Malignant tumors and hemostatic abnormalities, tumor cell proliferation and metastasis, on the one hand by the vascular endothelial cells, platelets, coagulation system and fibrinolytic system; the other hand, tumor cells produce pre-coagulation, pre-plasminogen activator , Also have an impact on the hemostatic mechanism .A first, the coagulation of tumor cells, fibrinolytic effect 1 to activate the fifth factor.Gordon et al observed in human and animal malignant tumor tissue, in addition to being able to separate the tissue thromboplastin-like Substance, there are still fifth factor activator and protease .Tumor cells can be directly activated factor 5. They also studied the V_2 rabbit pre-tumor coagulation