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目的探讨一氧化氮（ＮＯ）与蛛网膜下腔出血（ＳＡＨ）后脑血管痉挛的关系。方法测定２１例ＳＡＨ患者在病程第１～３天、第７～１０天和第３周脑脊液中ＮＯ和丙二醛（ＭＤＡ）含量，部分病例于病程第２周行全脑血管数字减影血管造影（ＤＳＡ）检查。结果患者脑脊液中ＮＯ含量于病程第７～１０天显著降低（Ｐ＜０．０１），至第３周含量有所增加，但仍低于病初（Ｐ＜０．０５）；经ＤＳＡ证实有脑血管痉挛的３例患者脑脊液中ＮＯ含量显著低于其他患者同时期含量；而ＭＤＡ含量变化与此相反，第７～１０天含量最高，至第３周降至病初水平。结论ＳＡＨ患者脑脊液中ＮＯ含量降低与脑血管痉挛的发生有关，脑脊液中自由基含量增多是ＮＯ含量降低的原因之一
Objective To investigate the relationship between nitric oxide (NO) and cerebral vasospasm after subarachnoid hemorrhage (SAH). Methods The contents of NO and malondialdehyde (MDA) in cerebrospinal fluid of 21 patients with SAH at the 1st, 2nd, 3rd, 10th, 10th and 3rd week of disease course were measured. In some cases, cerebrovascular digital subtraction angiography DSA) check. Results The content of NO in cerebrospinal fluid was significantly decreased (P <0.01) between the 7th and 10th days of the course of disease, and increased to the third week, but still lower than that of the early stage (P <0.05) The content of NO in cerebrospinal fluid in 3 patients with cerebral vasospasm was significantly lower than that of other patients in the same period. However, the content of MDA was the highest in the 7th to 10th days, but dropped to the initial level in the third week. Conclusions The decrease of NO in cerebrospinal fluid in patients with SAH is related to the occurrence of cerebral vasospasm. The increase of free radicals in cerebrospinal fluid is one of the reasons for the decrease of NO content