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本文以20例典型的EHF患者恢复后10～14个月的外周血,作了淋巴细胞姊妹染色单体互换(SCE)的检测。并以该EHF患者病期的SCE频率作了比较分析。还以10例健康者作对照。其结果表明:EHF患者SCE频率(10.4±0.17)较健康者(6.07±0.15)明显增高(P<0.01)。说明EHF病毒对患者外周淋巴细胞DNA有损伤效应。当患者脱离了EHF病毒作用、恢复出院后10～14个月(平均一年),经追踪观察,其SCE频率(6.25±0.10)表现明显降低(P<0.01)。EHF患者恢复后SCE(6.25±0.10)与健康者(6.07±0.15)比较,差异无显著性(P>0.05)其SCE频率已恢复至正常水平。
In this paper, 20 cases of typical EHF patients recovered 10 to 14 months after the peripheral blood, made the lymphocyte sister chromatid exchange (SCE) detection. The frequency of SCE in the EHF patients was compared. Also 10 healthy controls. The results showed that the frequency of SCE in EHF patients (10.4 ± 0.17) was significantly higher than that in healthy controls (6.07 ± 0.15) (P <0.01). EHF virus on patients with peripheral lymphocyte DNA damage effect. When the patient got rid of the EHF virus, he recovered 10 to 14 months after discharge (average one year). The follow-up observation showed that the SCE frequency (6.25 ± 0.10) decreased significantly (P <0.01). After SCE (6.25 ± 0.10) and healthy subjects (6.07 ± 0.15), there was no significant difference between the two groups (P> 0.05). The SCE frequency returned to normal after EHF recovery.