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人C-型逆转录病毒,人T-细胞性白血病/淋巴瘤病毒(HTLV),首先从美国黑人患者的成人T细胞恶性肿瘤细胞中分离而得.与这种病毒有关的T-细胞肿瘤不仅诊断困难,而且预后不良,因其用化疗难以获得持久的缓解,此外,尚易发生危及生命的高血钙以及卡氏肺囊虫和其它条件性致病菌感染.目前关于可能参与HTLV感染患者的肿瘤特异性细胞免疫反应的淋巴细胞尚知之甚少.作者研究了6例与HTLV有关的恶性疾病患者,目的是观察能否获得长期培养的针对HTLV感染的肿瘤细胞起反应的免疫T
Human C-type retrovirus, human T-cell leukemia / lymphoma virus (HTLV), was first isolated from adult T-cell malignant cells in African-American patients T-cell tumors associated with this virus not only Diagnosis is difficult, and the prognosis is poor, because it is difficult to obtain lasting relief with chemotherapy, in addition, is still prone to life-threatening hypercalcemia and Pneumocystis carinii and other opportunistic infections.At present, the possible involvement of patients with HTLV infection Of tumor-specific cellular immune response lymphocytes is still poorly understood.The authors studied 6 patients with HTLV-related malignancies, the purpose is to observe whether the long-term response to HTLV-infected tumor cells to respond to immune T