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目的 评估茶色素治疗消化性溃疡的临床疗效。方法 10 0例经胃镜诊断的消化性溃疡患者 ,随机分成两组 ,每组5 0例 ,采用双盲对照观察。治疗组 :茶色素 2 5 0mg ,2次 /日 ;对照组 :雷尼替丁 15 0mg ,2次 /日。 4周后胃镜复查。结果 10 0例消化性溃疡患者 ,失访 5例 (治疗组 3例 ,对照组 2例 ) ,95例完成治疗和胃镜复查。根据意图治疗分析 (ITT) ,治疗组治愈率为 80 % (42 /5 0 ) ,对照组治愈率为 88% (44 / 5 0 )。两组治愈率经统计学处理无显著差异 (P >0 5 )。对照组出现 4例AST轻度升高 ,治疗组未见副作用发生。结论 茶色素治疗消化性溃疡有良好的效果。
Objective To evaluate the clinical efficacy of tea pigment in the treatment of peptic ulcer. Methods One hundred and ten cases of peptic ulcer diagnosed by gastroscope were randomly divided into two groups of 50 cases, which were observed by double-blind control. Treatment group: tea pigment 250mg, 2 times / day; control group: ranitidine 150mg, 2 times / day. 4 weeks after endoscopy. Results 100 cases of peptic ulcer patients were lost in 5 cases (3 cases in the treatment group and 2 cases in the control group), and 95 cases completed the treatment and gastroscopy. According to Intent to Treat Analysis (ITT), the cure rate was 80% (42/50) in the treatment group and 88% (44/50%) in the control group. There was no significant difference between the two groups in the cure rate (P> 0.05). In the control group, 4 cases showed mild increase of AST, and no side effect occurred in the treatment group. Conclusion Tea pigment treatment of peptic ulcer has a good effect.