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目的:探讨超声造影(CEUS)在前列腺癌诊断中的临床应用价值。方法:应用超声造影剂声诺维(SonoVue)对经直肠穿刺病理证实的24例前列腺癌患者共32个外腺癌结节进行CEUS检查,观察结节的造影增强表现,并且绘制时间-强度曲线(TIC),定量分析造影剂到达时间(AT)、强度达峰时间(TTP)及峰值强度(PI)参数。结果:32个结节中,与外腺正常组织相比,造影呈现高增强的有27例,等增强和低增强各2例,无增强1例。31例增强结节的AT和TTP分别为(16.9±6.1)s和(29.1±9.7)s,低于正常外腺组织(20.2±6.6)s和(35.0±7.9)s(P<0.05),PI为(9.6±4.0)dB,高于正常外腺组织(7.5±3.8)dB(P<0.05)。结论:CEUS能较为客观地评价前列腺癌病灶内的血流供应情况,可以引导进行病灶的活检,TIC能对病灶进行定量参数分析,在临床上有助于前列腺癌的早期诊断。
Objective: To investigate the clinical value of contrast-enhanced ultrasound (CEUS) in the diagnosis of prostate cancer. Methods: CEUS was performed on 32 adenocarcinoma nodules in 24 patients with prostate cancer confirmed by pathological examination of the rectum by SonoVue. CEUS was performed to observe the enhancement of nodules’ contrast enhancement, and the time-intensity curve was drawn (TIC), quantitative analysis of contrast agent arrival time (AT), peak intensity time (TTP) and peak intensity (PI) parameters. Results: Twenty-two nodules had 27 cases with contrast enhancement compared with the normal tissue of the gland. There were 2 cases with equal enhancement and low enhancement and no enhancement with 1 case. The AT and TTP of 31 patients with enhanced nodules were (16.9 ± 6.1) s and (29.1 ± 9.7) s, respectively, which were lower than those of normal extrinsic tissues (20.2 ± 6.6 s and 35.0 ± 7.9 s (P <0.05) PI was (9.6 ± 4.0) dB higher than that of normal epistaxis (7.5 ± 3.8) dB (P <0.05). CONCLUSIONS: CEUS can objectively evaluate the blood flow in prostatic cancer lesions and guide the biopsy of lesions. TIC can quantitatively analyze the lesions and contribute to the early diagnosis of prostate cancer.