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目的:探讨人附睾蛋白4(HE4)、糖类抗原125(CA125)及磁共振(MRI)单项和联合检测对术前预测子宫内膜癌(EC)淋巴结转移的价值。方法:选择2015年2月至2017年4月在郑州大学附属肿瘤医院妇科收治的EC患者41例,检测血清CA125和HE4水平,并行盆腔MRI检查,对比三者单独或联合检测EC淋巴结转移的灵敏度及特异度。结果:三项指标单独检测EC淋巴结转移时,血清HE4价值最佳。当三者联合检测时,敏感度和阴性预测值较三者单项检测高。结论:HE4作为EC的肿瘤标志物,具有比CA125和MRI更好的诊断价值。
Objective: To investigate the value of single and combined detection of human epididymal protein 4 (HE4), carbohydrate antigen 125 (CA125) and magnetic resonance (MRI) in predicting endometrial carcinoma (EC) lymph node metastasis. Methods: From February 2015 to April 2017, 41 patients with EC in gynecological department of Affiliated Tumor Hospital of Zhengzhou University were enrolled. The serum levels of CA125 and HE4 were detected and pelvic MRI examination was performed. The sensitivity of the three methods for detecting EC lymph node metastasis And specificity. Results: The three indicators of EC lymph node metastasis alone, the best value of serum HE4. When the three were tested jointly, the sensitivity and negative predictive value were higher than those of the three tested individually. Conclusion: HE4 as a tumor marker of EC has better diagnostic value than CA125 and MRI.