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山莨菪碱是我国学者从唐古特茛菪中分离出的生物碱。654-2为其合成品。作为一种M-胆碱受体阻断药,山莨菪碱也有扩瞳作用。在动物身上,其扩瞳作用较阿托品约弱10倍;但山莨菪碱对人眼睫状肌的麻痹作用尚未见报道。为了具体了解该药对眼睫状肌的麻痹作用,我们于1984年10月8日～11月15日,将山莨菪碱与后马托品分别、同时滴入患者的左右眼,进行散瞳验光,测定剩余调节力。结果发现,同样浓度和用量的山茛菪碱较后马托品的调节麻痹作用强(两者的剩余调节力有非常显著性差异),且药物作用时间短(仅1～2天),无全身反应,局部反应少。因此山茛菪碱用作睫状肌麻痹较后马托品优越。
Anisodamine is an alkaloid that Chinese scholar has isolated from Houttuynia. 654-2 for its synthetic products. As an M-choline receptor blocker, anisodamine also has a dilation effect. In animals, the role of pupil dilation is about 10 times weaker than atropine; but anisodamine on the human eye ciliary muscle paralysis has not been reported. In order to understand the paralysis of the drug on the ciliary muscles of the eye, we in October 8, 1984 to November 15, anisodamine and horsutar respectively, while dripping into the left and right eyes of patients, mydriasis Optometry, determination of the remaining regulatory force. The results showed that the same concentration and dosage of anisodamine than the paraquat paraquat strong paraquat (the remaining regulatory power has a very significant difference), and the drug action time is short (only 1 to 2 days), no Systemic reactions, local reactions less. Anisodamine is therefore superior to cortico-paralysis for the latter.