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钙拮抗剂的基本作用是阻滞心肌及平滑肌(如冠脉或外周血管平滑肌)细胞的慢Ca~(2+)通道,抑制Ca~(2+)向细胞的内流,故又称钙通道阻滞剂(或抑制剂)。电生理研究证实,心肌细胞动作电位曲线中0相的快速上升是由于Na~+内流所致,钙拮抗剂不影响或很少影响其过程;2相的平台由Ca~(2+)内流所维持,故能被钙拮抗剂所抑制。而属于慢自律细胞的窦房结和房室
The basic function of calcium antagonists is to block the slow Ca 2+ channel of myocardial and smooth muscle (such as coronary artery or peripheral vascular smooth muscle) cells and inhibit the influx of Ca 2+ into cells, so calcium channel Blockers (or inhibitors). The electrophysiological studies confirmed that the rapid increase of 0 phase in the action potential curve of cardiomyocytes was due to the influx of Na ~ +, and the calcium antagonist did not affect or seldom affect the process. The 2-phase plateau consisted of Ca 2+ Flow is maintained, it can be inhibited by calcium antagonists. And belong to the slow self-regulatory cells of the sinus node and atrioventricular