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目的:探讨姜黄素对二甲基苯并蒽(DMBA)诱发的新西兰大白兔口腔癌的预防作用。方法:通过DMBA诱发新西兰大白兔口腔癌模型,同时用1.0、0.3 g/kg姜黄素进行干预,进行口腔肿瘤发生率、癌变率、微核细胞率、细胞增殖核抗原(PCNA)和上皮生长因子受体(EGFR)检测。结果:高剂量姜黄素组(1.0%)、低剂量姜黄素组(0.3%)平均抑制肿瘤的能力即简称肿瘤负荷抑制率分别为75.6%、61.2%;癌变率、微核细胞率和增殖细胞核抗原(PCNA)标记指数与阳性对照组比较明显降低,然而对上皮生长因子受体(EGFR)的表达无干扰。结论:姜黄素对二甲基苯并蒽(DMBA)诱发的新西兰大白兔口腔癌有良好的干预效应,同时不影响新西兰大白兔本身的成长。
Objective: To investigate the preventive effect of curcumin on oral cancer in New Zealand white rabbits induced by dimethylbenz (a) anthracene (DMBA). Methods: New Zealand white rabbits model of oral cancer was induced by DMBA. At the same time, 1.0, 0.3 g / kg curcumin was used for the intervention. The incidence of oral cancer, carcinogenesis, micronuclei, proliferating cell nuclear antigen (PCNA) and epithelial growth factor Receptor (EGFR) assay. Results: The average inhibitory rates of tumors in high dose curcumin group (1.0%) and low dose curcumin group (0.3%) were 75.6% and 61.2%, respectively. The rates of canceration, micronucleus and proliferating cell nucleus Antigen (PCNA) labeling index decreased significantly compared with the positive control group, however, it did not interfere with the expression of epidermal growth factor receptor (EGFR). CONCLUSION: Curcumin has a good intervention effect on DMBA-induced New Zealand white rabbits oral cancer and does not affect the growth of New Zealand white rabbits.