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目的:探讨乙型肝炎病毒表面抗原(hepatitis Bsurface antigen,HBsAg)阳性母亲其新生儿出生时HBsAg与乙型肝炎病毒脱氧核苷酸(hepatitis B virus DNA,HBV-DNA)同时阳性对HBV宫内感染的诊断价值。方法:选择1 532例分娩孕妇及其对应新生儿1 545例(双胎13例),检测新生儿出生时HBsAg和HBV-DNA,复查1月龄时HBsAg,计算HBV宫内感染率,分析HBsAg与HBV-DNA同时阳性对HBV宫内感染初步诊断的准确性。结果:1 545例新生儿中,HBsAg和HBV-DNA同时阳性者36例(2.33%)。至1个月龄时剔除失访148例后,随访婴儿出生时HBV-DNA阳性36例中32例持续HBsAg阳性,而出生时HBsAg阳性、HBV DNA阴性婴儿中10例HBsAg持续阳性,HBV宫内感染率2.72%(42/1545);与出生时HBsAg和HBV-DNA同时阳性率2.33%相近。结论:HBsAg阳性母亲其新生儿出生时HBsAg和HBV-DNA同时阳性可作为HBV宫内感染的初步诊断指标。
Objective: To investigate the relationship between HBsAg and hepatitis B virus DNA (HBV-DNA) in hepatitis B virus positive mothers (HBsAg) positive mothers The diagnostic value. Methods: A total of 1 532 cases of pregnant women and their corresponding newborns were enrolled in this study, including 1 545 newborns (13 twins). HBsAg and HBV DNA were detected at birth and HBsAg at 1 month of age. HBV intrauterine infection Accuracy of preliminary diagnosis of intrauterine HBV infection with HBV-DNA positive. Results: Among 5445 newborns, 36 (2.33%) were HBsAg positive and HBV-DNA positive at the same time. Of the 148 patients who were lost to follow-up at one month of age, 32 of the 36 patients who were HBV-DNA positive at follow-up were persistent HBsAg positive and HBsAg were positive at birth, 10 were HBsAg positive in HBV DNA-negative infants, The infection rate was 2.72% (42/1545), similar to the positive rate of HBsAg and HBV-DNA at birth of 2.33%. Conclusions: Simultaneous positive HBsAg and HBV-DNA at the time of newborns HBsAg positive mothers can be used as a preliminary diagnostic indicator of HBV intrauterine infection.