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目的:总结国内外关于结直肠癌淋巴管生成方面的研究进展。方法:以“结直肠癌、淋巴管生成、淋巴管生成因子和淋巴道转移”为关键词,检索CNKI和PubMed数据库1996-01-2010-11的相关文献,共检索到英文文献472篇,中文文献102篇。纳入标准:1)结直肠癌淋巴道转移机制的研究;2)淋巴管内皮细胞相关标志的研究;3)淋巴管生成因子在结直肠癌转移中作用的研究;4)抗肿瘤淋巴管生成治疗。根据纳入标准,纳入分析30篇文献。结果:淋巴管生成是结直肠癌淋巴道转移的重要步骤,淋巴管生成因子可通过多条途径促进淋巴管生成,对于抑制淋巴管生成是否一定能阻断淋巴道转移尚存在争论。结论:有必要将形态学和功能学方法相结合,进一步阐明各种淋巴管生成因子促进淋巴管生成的机制,为抗肿瘤治疗提供新的靶点。
Objective: To summarize the research progress of lymphangiogenesis in colorectal cancer at home and abroad. METHODS: The key words of colorectal cancer, lymphangiogenesis, lymphangiogenesis factors and lymphatic metastasis were retrieved from CNKI and PubMed databases from January 1996 to November 2010 with 472 articles retrieved , 102 Chinese literature. Inclusion criteria: 1) the study of lymphatic metastasis of colorectal cancer; 2) the study of markers of lymphatic endothelial cells; 3) the role of lymphangiogenesis factors in the metastasis of colorectal cancer; 4) anti-lymphangiogenesis therapy . According to the inclusion criteria, 30 articles were included in the analysis. Results: Lymphangiogenesis is an important step in lymphatic metastasis of colorectal cancer. Lymphangiogenesis factors can promote lymphangiogenesis through multiple pathways. It is controversial whether lymphangiogenesis can be blocked by lymphangiogenesis. Conclusion: It is necessary to combine morphological and functional methods to further elucidate the mechanism of various lymphangiogenesis factors in promoting lymphangiogenesis, and provide a new target for anti-tumor therapy.