降钙素基因相关肽（CGRP）是首次应用基因工程方法发现的一种舒血管生物活性肽。它对多种器官均有细胞保护作用，能预防缺血再灌注造成的肝脏损伤，减轻肝脏脂质过氧化反应[1]。国内对CGRP与肝硬化门脉高压的关系少有报道。本文报道肝硬化患者血浆CGRP水平的变化，探索它在肝硬 Calcitonin gene-related peptide (CGRP) is the first biologically active peptide found by gene engineering. It has a variety of organ cell protection, can prevent liver damage caused by ischemia-reperfusion, reduce liver lipid peroxidation [1]. Domestic CGRP and cirrhosis portal hypertension rarely reported. This article reports the changes of plasma CGRP levels in cirrhotic patients and explores its role in liver cirrhosis