Objective: To observe the clinical characteristics of acute exacerbation of chronic obstructive pulmonary disease (AECOPD)caused by influenza virus, and to explore the distribution of Chinese medical syndromes. Methods: A retrospective study method was used to collect 66 patients with infectious AECOPD who were hospitalized in the Department of Respiratory Medicine of Wangjing Hospital from January 2016 to December 2020.They were divided into the infected group and the negative group according to whether they were infected with influenza virus.The patients were collected for general clinical practice Data (sex,age,course of disease,whether fever this time),inflammation index levels(procalcitonin PCT,C-reactive protein CRP,white blood cell count WBC,neutrophil percentage NEUT％,monocyte percentage MONO％,lymphocytes Percent LYM％),lung function(vital capacity VC,forced vital capacity FVC,forced expiratory volume FEV1 in 1 second,FEV1/FVC in 1 second),arterial blood gas analysis(arterial blood oxygen partial pressure PaO2, arterial blood carbon dioxide partial pressure PaCO2)And so on.Spearman correlation analysis was used to analyze the clinical characteristics of infectious AECOPD caused by influenza virus.Summarize the distribution law of TCM syndromes. Results: Patients in the infected and negative group were at age[77(69,80) vs 67(62,78)years],the proportion of patients with fever[14(38.89％) vs 4(13.33％)],PCT[0.059(0.041,0.085)ng/ml vs 0.040(0.028,0.068)ng/ml],CRP[20.42(2.61,60.99)mg/L vs 5.01(1.51,16.55)mg/L],LYM％(17.10±6.81) vs 20.96±8.68),PaO2[71.75(62.85,77.90) mmHg vs 75.15(68.18, 80.23)mmHg]and other indicators,there are significant differences,and the difference is statistically significant (P<0.05).Spearman correlation analysis showed that compared with the negative group,patients with infectious AECOPD caused by influenza virus were older,often had fever,and had higher levels of PCT and CRP. Conclusion: If AECOPD patients are elderly,have fever symptoms,and the levels of inflammation indicators PCT and CRP are high,influenza virus infection can be considered.TCM syndromes are mainly based on phlegm-heat stagnation in the lung,often combined with yin deficiency,qi deficiency,qi and yin deficiency and blood stasis;the viscera often involves lung,spleen,and kidney.