Objective: To observe the effect of Yishen Sanjie Huayu compound prescription on ERK/NF-κB signaling pathway in IgA nephropathy (IgAN) rats, and explore its effect on preventing and treating IgA nephropathy intrarenal arteriole disease. Methods: Fifty-five male SD rats were randomly divided into blank group, model group, Shenfukang Ⅱ capsule group and Losartan potassium tablet group. Bovine serum albumin (BSA) was used for intragastric administration and carbon tetrachloride (CCl4). ) IgAN rat model was established by subcutaneous injection and lipopolysaccharide (LPS) tail vein injection. Shenfukang Ⅱ capsule group and Losartan potassium tablet group were given each drug suspension 2ml/head/d one week after modeling Gavage was started. The blank group and the model group were given an equal volume of normal saline. The 24h urine protein (UTP) of the rats was measured at 4, 8, and 12 weeks after the administration, and the blood creatinine (SCr) was measured after 12 weeks. ), urea nitrogen (BUN), aldosterone (ADS), angiotensin Ⅱ (Ang Ⅱ), immunohistochemical Envi-sion System two-step method to detect vascular endothelial growth factor (VEGF) and human matrix in the whole rat kidney and small artery area The expression of metalloproteinase-9 (MMP-9), proliferating cell nuclear antigen (PCNA), extracellular regulatory protein kinase (ERK) 1/2, nuclear transcription factor-κB (NF-κB), and the small arteries of rat kidney tissue The intima, media, vessel wall/vascular outer diameter value. Results: Compared with the model group, the expressions of VEGF, MMP-9, PCNA, ERK1/2 and NF-κB in kidney tissues of the Shenfukang Ⅱ capsule group and the Losartan potassium tablet group decreased (P<0.05), 24hUTP and SCr , BUN level decreased (P<0.05), kidney tissue damage was alleviated; intima and vessel wall/vascular outer diameter values were significantly reduced (P<0.01), there was no significant difference in ADS between the groups. The AngⅡ of the Tanpotassium tablets group was lower than that of the model group (P<0.05). Conclusion: Yishen Sanjie Huayu compound can inhibit the ERK/NF-κB signaling pathway in rats with IgA nephropathy, reduce the levels of VEGF, MMP-9, PCNA, ERK1/2, NF-κB, and inhibit intrarenal arteriole vascular endothelial cells Proliferate and reduce kidney damage.