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白内障囊外手术时,手术操作常引起瞳孔缩小,使去除晶体皮质和置入后房型人工晶体发生困难。为保持术中扩瞳,某些医生将肾上腺素放在冲洗和灌注瓶内,有些医生喜用肾上腺素注入前房。眼内用肾上腺素的最初试验是眼内注入1:1000肾上腺素,少数病例发生严重角膜失代偿,认为这是由肾上腺素制剂内重亚硫酸钠防腐剂的毒性引起。临床上采用1:10000或更稀的浓度,术后角膜情况良好,但尚未证实更稀浓度的有效或无效的剂量反应资料。本文用随机双盲试验获得术中肾上腺素扩瞳的剂量反应资料,并分析与其有关的虹膜色泽、用药前瞳孔直径、病人年龄、性别及术前扩瞳等因素。本组包括Jules Stein眼科医院1981年9月～1982年2月55例白内障囊外手术时眼内用肾上腺素维持扩瞳的病例,平均年龄72岁(55～93岁),男23例,女22例。37例术前局部用2.5%
Cataracts extracapsular surgery, surgical procedures often cause miosis, the removal of the crystalline cortex and posterior chamber intraocular lens implantation difficulties. In order to maintain intraoperative pupil dilation, some doctors put epinephrine in irrigation and perfusion bottles, some doctors like to use adrenaline into the anterior chamber. The first trial of intraocular epinephrine was intra-ocular injection of 1: 1000 epinephrine, with a few cases of severe corneal decompensation believed to be caused by the toxicity of sodium bisulfite preservatives within the epinephrine formulation. Clinical use of 1: 10000 or more dilute concentration, postoperative cornea is good, but no more confirmed the concentration of effective or ineffective dose response data. In this paper, randomized double-blind experiment was used to obtain dose-response data of intraoperative adrenal dilation and to analyze the iris color, the pupillary diameter before treatment, the patient’s age, sex and the preoperative pupil dilation. This group includes Jules Stein ophthalmic hospital in September 1981 ~ February 1982 55 cases of cataract surgery outside the eye with adrenaline to maintain dilated pupil cases, mean age 72 years (55 to 93 years), 23 males and females 22 cases. 37 cases of preoperative local 2.5%