作者在研究延胡索乙素(dl-tetrahydropalmatine,THP,简称乙素)的化学结构与疗效关系时,发现四氢小檗硷(tetrahydroberberine,THB,简称 N-1)的药理作用与乙素颇类似。进一步的研究证实 N-1的镇痛作用弱于乙素,而镇静镇定作用较乙素为明显;临床观察指出 N-1对更年期精神病人有一定疗效;用它治疗精神分裂症患者时,观察到病人的许多表现与镇定剂氯丙嗪或利血平出现疗效前的症状颇类似。这些结果引起作 When studying the chemical structure and therapeutic effect of tetrahydropalmatine (THP), we found that the pharmacological action of tetrahydroberberine (THB, referred to as N-1) is quite similar to that of B. Further study confirmed that the analgesic effect of N-1 is weaker than that of B, while the sedation and calming effect is more obvious than that of B; clinical observation indicates that N-1 has some curative effect on menopausal mental patients; when it is used to treat patients with schizophrenia, Much of the performance to the patient is quite similar to that before the onset of efficacy of the tranquilizers chlorpromazine or reserpine. These results aroused