許多甾体化合物,如性激素、心脏有效素等具有重要生理作用,且已用于临床。近年来許多学者均致力于有效甾体物結构与疗效間关系的研究,希望得到具有很強生理作用而又有比較簡单分子結构的甾体物。其中部分的工作是19-去甲基甾体化合物結构改变的研究。在1944年Ehrenstein选择了毒毛旋花子配基Strophanthindin(Ⅰ)为原料以合成19-去甲基黃体酮,因为毒毛旋花子配基分子中19位碳上是一个醛基,易于設法除去。此物經药理試驗証明有比黃体酮更高的生理活力。虽然如此,19-去甲基甾体物仍然沒有 Many steroidal compounds, such as sex hormones, cardioversion has important physiological effects, and has been used in clinical. In recent years, many scholars have devoted themselves to the study of the relationship between effective steroid structure and therapeutic effect, hoping to obtain the steroid with a strong physiological function and a relatively simple molecular structure. Part of the work is the study of the structural changes in 19-demethyl steroids. In 1944 Ehrenstein selected the poisonous hair spinach strigotrin ligand Strophanthindin (I) as the raw material for the synthesis of 19-nor-methyl progesterone, because the poisonous hair spinach ligand molecules in 19 carbon is an aldehyde group, easy to manage to remove . This material by pharmacological tests proved higher than the progesterone physiological activity. Nonetheless, 19-demethyl steroids are still missing