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对12例强直性脊柱炎(AS)患者进行外周血淋巴细胞(PBL)亚群、体外培养产生IL-2的能力以及自然杀伤(NK)细胞活性测定。结果表明,AS患者PBLT_4、T_8阳性细胞百分率及T_4/T_8比值与正常人相比无显著差异;PBL体外培养产生的IL-2明显增多,但细胞膜IL-2受体表达无明显增多;NK细胞活性明显降低,且对IL-2刺激无反应。本结果提示,AS患者存在明显的细胞免疫功能紊乱,并在导致体液免疫异常中起重要作用。
Peripheral blood lymphocyte (PBL) subsets were cultured in 12 patients with ankylosing spondylitis (AS), and their ability to produce IL-2 in vitro and natural killer (NK) cell activity were determined. The results showed that the percentage of PBLT_4 and T_8 positive cells and the ratio of T_4 / T_8 in AS patients were not significantly different from those in normal subjects. IL-2 produced by PBL in vitro increased significantly but IL-2 receptor expression was not significantly increased in AS patients. Activity was significantly reduced, and no response to IL-2 stimulation. The results suggest that AS patients have obvious cellular immune dysfunction, and lead to humoral immune abnormalities play an important role.