中性白细胞计数明显地影响抗菌素的治疗效果,以银他霉素治疗的63例癌症病人为例,中性白细胞<100、101～1000及>1000/mm~3病人的治愈率分别为23%、53%及79%。由于中性白细胞减少者对感染缺乏足够的炎症性反应能力,故依赖抗菌素控制感染,本文就间断给药和持续给药两种不同的给药方案与治疗效果进行探讨。中性白细胞减少伴发绿脓杆菌感染以羧噻吩青霉素治疗,每次5g,给药时间2小时,每6小时给药1次,则5人中仅2人治愈,6小时末的平均血浓度仅为19μg/ml;如给药方法改为每次3.5g,给药时间亦为2小时,每4小时给药1次,病人的治愈率则达74%(32/42),其平均高峰血浓度为210μg/ml,血清浓度可维持在50μg/ml 左右。白细胞正常的感染病人,以丁胺卡那霉素间断给药,而中性白细胞减少的病人则连续给药,两组的治愈率相仿,分别为61%和66%。中性白细胞减少病人,应用西梭霉素连续静脉滴注给药者治愈率为61%,显然高于间断给药者(46%)。对治疗开始前肾功能正常者予以连续静脉滴注的 Neutrophil counts significantly affect the therapeutic effect of antibiotics, with 63 patients treated with silver thalidomide as an example, the neutrophils <100,101 ~ 1000 and> 1000 / mm ~ 3 the cure rate of patients were 23% , 53% and 79% respectively. Because neutropenic patients lack adequate inflammatory response to infection, it is dependent on antibiotics to control infection. In this paper, two different dosing regimens and therapeutic effects are discussed intermittently and continuously. Neutropenia associated with Pseudomonas aeruginosa infection with carboxyfenthib penicillin treatment, each 5g, dosing time of 2 hours, administered once every 6 hours, then 5 were cured only 2, 6 hours the end of the average blood concentration Only 19μg / ml; if the method of administration changed to 3.5g each time, the administration time is also 2 hours, once every 4 hours, the patient’s cure rate is up to 74% (32/42), the average peak Blood concentration of 210μg / ml, serum concentration can be maintained at about 50μg / ml. Patients with normal leukocyte infection were given intermittent administration of amikacin, whereas neutropenic patients were given consecutively, with similar rates of cure of 61% and 66% in both groups. Neutropenic patients, the application of continuous intravenous infusion of strychnine, the cure rate was 61%, apparently higher than intermittent dosing (46%). The treatment of patients with normal renal function before the continuous intravenous infusion