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内源性阿片肽（ EOP）是机体中一类十分重要的神经肽。因其不同类型的配体介导着不同类型的效应活性，并且配体之间无交叉耐受，所以在机体中调节着许多不同的生理活动。当机体发生肝硬化时，体内脑啡肽、β-内啡肽、强啡肽的含量明显升高，故考虑当肝硬化及其并发症发生时，体内升高的EOP可能参与了其发生、发展过程。通过研究EOP及其拮抗剂的作用机制，可以为临床治疗肝硬化及其并发症找到一种新的方法。“,”Endogenous opioid peptide(EOP) is a very important kind of nervous peptide in the body. They regulate many different physiological functions ,because there is no cross tolerance between different lig-ands,which mediate different types of effect activity .The contents of enkephalin,β-endorphin and dynorphin would increase apparently when liver cirrhosis develops.So it′s considered that the increased EOP might be involved in the development and complications of liver cirrhosis .A new way to treat the liver cirrhosis and its complications might be found by studying the action mechanisms of EOP and its antagonists .