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目的探讨中国人脂朕素基因SNP-11391G/A和-11371C/G位点变异与2型糖尿病发病的关系。方法运用PCR-RFLP技术在258例(86例非糖尿病者和172例2型糖尿病患者)大连地区汉族人检测APN基因SNP-11377C/G和-11391G/A变异情况,分析其与2型糖尿病发病的相关性。结果-11377C/G多态性与糖尿病发病无关,-11391G/A多态性与2型糖尿病发病相关(χ2=7.662,P<0.005)。结论APN基因-11391A基因变异可能与变异携带者胰岛细胞代偿功能相关。
Objective To investigate the relationship between the polymorphisms of Chinese lipoperoxidin gene SNP-11391G / A and -11371C / G and the pathogenesis of type 2 diabetes mellitus. Methods The polymorphisms of APN gene SNP-11377C / G and -11391G / A were detected in 258 Chinese patients (86 non-diabetics and 172 type 2 diabetics) by PCR-RFLP in Dalian area of China. Relevance. Results The -11377C / G polymorphism was not associated with diabetes. The -11391G / A polymorphism was associated with the onset of type 2 diabetes (χ2 = 7.662, P <0.005). Conclusion The variation of APN gene-11391A gene may be related to compensatory function of islet cells in the variant carriers.