口服固体制剂的溶出测定是预测药物生物有效性的一种重要措施。通常用水、稀盐酸或缓冲液作溶媒。但因含油药物制剂和水不溶性药物制剂不溶于这些溶媒,一般的溶出测定法不适用,为此已研究出了数种溶出测定方法。如:20L 容器及大量溶媒的方法、二相法,加合成表面活化剂法和使用混合溶媒法。把合成表面活化剂或乙醇加入溶 Dissolution of oral solid preparations is an important measure to predict the bioavailability of the drug. Usually water, dilute hydrochloric acid or buffer as a solvent. However, since the oily pharmaceutical preparations and the water-insoluble pharmaceutical preparations do not dissolve in these solvents, the general dissolution assay is not applicable, and for this reason, several dissolution test methods have been developed. Such as: 20L containers and a large number of solvent methods, two-phase method, plus the surface active agent method and the use of mixed solvent method. Add synthetic surfactant or ethanol to the solution