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离体原头蚴经1％甲苯咪唑药液处理48小时死亡率为50.4％,经152小时,原头蚴全部死亡,对照组死亡率为34％。用O.5％甲苯咪唑悬液对阳性小鼠进行腹腔注射2ml/天,共12次,腹腔内棘球蚴全部萎陷,角皮层变性,生发层坏死,周围有细胞反应。用甲苯咪唑1g/kg饲料(近似50mg/kg bw/d)喂感染棘球蚴小鼠60天、100天,疗效均不彻底,在囊团内有残存活囊。用甲苯咪唑3g/kg饲料(近似150mg/kg bw/d)喂100天,20只鼠腹腔棘球蚴全部萎陷崩溃、囊壁变性坏死,周围有细胞反应。国产甲苯咪唑对动物棘球蚴及原头蚴有直接致死作用。疗效与药量和饲期有关。
The protozoae larvae were treated with 1% mebendazole for 48 hours and the mortality rate was 50.4%. After 152 hours, all the protozoa were dead, the control group mortality was 34%. Positive mice were inoculated intraperitoneally with 2 ml / day of O.5% mebendazole suspension for 12 times. Echinococcosis in the abdominal cavity collapsed, keratoconus degeneration, germinal layer necrosis and cellular reaction around. Echinococcosis mice were challenged with mebendazole 1 g / kg diet (approximately 50 mg / kg bw / d) for 60 days and 100 days without complete efficacy and residual viable sac in the balloon. With mebendazole 3g / kg feed (approximately 150mg / kg bw / d) for 100 days, 20 mice encephalic hydatid cyst collapsed collapsed, degeneration and necrosis of the capsule wall around the cell response. Domestic mebendazole has a direct lethal effect on hydatid cysts and protozoa. Efficacy and dose and feeding related.