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目的：探讨抗－ＨＥＶＩｇＧ和ＩｇＭ阳性对急性戊型肝炎（急性戊肝）的诊断价值。方法：应用酶联免疫法（ＥＬＩＳＡ）检测非肝炎住院患者血清抗－ＨＥＶＩｇＧ。结果：在３６９例非肝炎患者中，阳性３３例（８．９％），再经不同批号的试剂复测，此３３例血清仍阳性者２８例，符合率８５％，检测其抗－ＨＥＶＩｇＭ，阳性者４例。而确诊为急性戊肝的２０例患者，复检血清抗－ＨＥＶＩｇＧ阳性率仍１００％，抗－ＨＥＶＩｇＭ阳性率８０％。结论：（１）急性戊肝早期抗－ＨＥＶＩｇＧ和ＩｇＭ均可阳性。若ＩｇＭ阴性时，结合临床表现、肝功能检查、肝炎病毒感染标志检测，抗－ＨＥＶＩｇＧ阳性对急性戊肝仍有早期诊断意义；（２）在非肝炎患者或健康人中，可以出现抗－ＨＥＶＩｇＧ和ＩｇＭ阳性，前者为既往隐性感染，后者为近期隐性感染。
Objective: To investigate the diagnostic value of anti-HEVIgG and IgM in the diagnosis of acute hepatitis E (acute hepatitis E). Methods: Serum anti-HEVIgG was detected by enzyme-linked immunosorbent assay (ELISA) in non-hepatitis inpatients. Results: Of the 369 non-hepatitis patients, 33 (8.9%) were positive and re-tested by different batches of reagents. These 33 cases were still positive in 28 cases, with a coincidence rate of 85%. The anti-HEVIgM, Positive in 4 cases. In the 20 patients diagnosed with acute hepatitis E, the positive rate of serum anti-HEVIgG was 100% and the positive rate of anti-HEVIgM was 80%. Conclusions: (1) The anti-HEVIgG and IgM can be positive in the early stage of acute hepatitis E virus. If IgM negative, combined with clinical manifestations, liver function tests, detection of hepatitis virus infection signs, anti-HEVIgG positive acute hepatitis E still have early diagnostic significance; (2) in non-hepatitis patients or healthy people, anti-HEVIgG And IgM positive, the former is a hidden recessive infection, which is the recent recessive infection.