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[目的]观察不同单次大剂量外放疗对猪胰腺及胰周组织的损伤作用。[方法]12头家猪分为7Gy、10Gy、13Gy和16Gy共4组,每组3头进行单次大剂量外放疗,取仰卧位,前后对穿照射,射野面积为10cm×10cm方野,照射后7d处死动物后取材,取受照胰腺组织及胰周组织进行常规切片HE染色,光镜下病理观察。[结果]单次大剂量照射后猪胰腺组织的损伤呈明显的剂量依赖性,损伤形式由点状凋亡坏死向大片状坏死转变。[结论]提高单次照射剂量在增加胰腺组织损伤的同时也明显增加了胰周组织的损伤。因此,应采用调强适形放疗技术加强对胰周组织的保护。提高单次剂量后引起的胆道损伤应引起注意。
[Objective] To observe the injury of porcine pancreas and peri-pancreatic tissue under different single-dose external radiotherapy. [Method] The 12 domestic pigs were divided into 4 groups of 7Gy, 10Gy, 13Gy and 16Gy. Each group of 3 pigs were given large dose of external radiotherapy. The supine position was adopted. The area of the pigs was 10cm × 10cm The animals were sacrificed on day 7 after irradiation. The pancreas and peri-pancreatic tissues were harvested and stained with routine HE staining. The pathological changes were observed under light microscope. [Result] The damage of porcine pancreas tissue was significantly dose-dependent after a single high-dose irradiation. The damage form was changed from punctate necrosis to large-scale necrosis. [Conclusion] Increasing the dose of single irradiation increased pancreatic tissue injury at the same time as pancreatic tissue injury. Therefore, should be used to strengthen the conformal radiotherapy technology to strengthen the peri-pancreatic tissue protection. Increased single dose caused by biliary injury should be noted.