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目的观察厄贝沙坦氢氯噻嗪治疗老年性高血压的临床疗效。方法将符合病例入选标准的120例老年高血压患者按就诊的先后顺序随机分为观察组、对照组,各60例。2组均嘱患者调畅情志,清淡饮食。对照组同时给予卡托普利片,25 mg/次,每日2次,餐前服用。观察组同时给予厄贝沙坦氢氯噻嗪片,每日1次,每次1片,餐前服用。2组均以治疗2周为1个疗程。观察2组治疗前后血压的变化情况、不良反应并综合上述指标评价临床疗效。结果显效率观察组为80.00%,对照组为66.67%,2组相比差异有统计学意义(P﹤0.05);总有效率为观察组为91.67%,对照组为76.67%,2组相比差异有统计学意义(P﹤0.05)。2组治疗前组间相比差异无统计学意义(P﹥0.05);治疗1个疗程后舒张压(DBP)、收缩压(SBP)均明显下均,与治疗前相比差异有统计学意义(P﹤0.05),但治疗后2组相比差异无统计学意义(P﹥0.05)。治疗2、3、4个疗程后观察组SBP、DBP下降较对照组明显,与对照组相比差异有统计学意义(P﹤0.05)。2组肝肾功能治疗前后差异无统计学意义(P﹥0.05)。结论厄贝沙坦氢氯噻嗪治疗老年性高血压疗效明显。
Objective To observe the clinical efficacy of irbesartan hydrochloride in the treatment of senile hypertension. Methods A total of 120 elderly patients with hypertension were enrolled in the observation group and the control group according to the order of treatment. 2 patients are Zhu Huanzhe emotional tone, light diet. The control group was given captopril tablets, 25 mg / time, twice daily, before meals. The observation group was given irbesartan hydrochloride hydrochlorothiazide tablets once daily for 1 tablet before meals. 2 groups were treated for 2 weeks for a course of treatment. The changes of blood pressure before and after treatment were observed in two groups. Adverse reactions and the above indexes were used to evaluate the clinical efficacy. Results The effective rate was 80.00% in the observation group and 66.67% in the control group. There was significant difference between the two groups (P <0.05); the total effective rate was 91.67% in the observation group and 76.67% in the control group, compared with the control group The difference was statistically significant (P <0.05). There was no significant difference between the two groups before treatment (P> 0.05). After one course of treatment, the diastolic blood pressure (DBP) and systolic blood pressure (SBP) were obviously lower than before treatment, and the difference was statistically significant (P <0.05), but there was no significant difference between the two groups after treatment (P> 0.05). After treatment for 2, 3, and 4 courses, the decrease of SBP and DBP in the observation group was more obvious than that in the control group, and the difference was statistically significant compared with the control group (P <0.05). There was no significant difference between the two groups before and after treatment of liver and kidney function (P> 0.05). Conclusion Irbesartan hydrochlorothiazide treatment of senile hypertension obvious curative effect.