论文部分内容阅读
选用马属动物驴和大白鼠为实验对象，按中医病因原理用多种方法建立脾气虚证动物模型，从生理学、病理学、细胞学、生物化学、免疫学、电镜学多角度，从宏观到微观，从形态到功能系统地对脾主运化、脾主肌肉、脾统血、脾旺不受邪进行研究。结果表明：（１）脾主肌肉包括了骨骼肌、胃肠平滑肌、心肌和血管平滑肌，以至于血小板那样具有肌球蛋白结构和肌力收缩功能的组织。（２）心肌和血管平滑肌线粒体的改变，以及心肌糖原、脂类物质减少，血小板收缩聚集能力下降，毛细血管脆性增加是脾不统血的主要表现。（３）红细胞膜蛋白变构，小肠微绒毛破坏，组织中糖原和脂类能源物质不足，氧化磷酸化作用下降构成的脾气虚中脾主运化在物质能量代谢方面最基本的内容。（４）脾旺不受邪包括免疫调节和屏障功能。（５）脾病胃亦病。该结果提示脾气虚证的发生机制，首先是在脾主运化的物质能量转化利用这个主要环节上。
The equine animal donkey and the rats were selected as experimental subjects. According to the etiology of TCM, animal models of spleen-qi deficiency syndrome were established by a variety of methods. From macroscopic perspectives of physiology, pathology, cytology, biochemistry, immunology and electron microscopy, Micro, from the morphological to functional system of the spleen main transport, spleen and muscle, spleen and blood, spleen without evil research. The results showed that: (1) Spleen and main muscles include skeletal muscle, gastrointestinal smooth muscle, cardiac muscle and vascular smooth muscle, so that platelet has myosin structure and contractile function of the organization. (2) Changes of mitochondria in myocardium and vascular smooth muscle, as well as the reduction of cardiac glycogen, lipids, platelet contraction and aggregation ability, and the increase of capillary fragility are the main manifestations of spleen incompetence. (3) the most basic content of the energy metabolism of the spleen in the spleen qi, which is the alloplasm of the erythrocyte membrane protein, the destruction of the intestinal microvilli, the lack of glycogen and lipid energy substances in the tissues, and the oxidative phosphorylation. (4) spleen Wang not immune including immune regulation and barrier function. (5) spleen and stomach disease. The results suggest that the mechanism of the spleen qi deficiency syndrome, the first is the main transport of energy in the spleen host material transformation and utilization of this.