论文部分内容阅读
土拨鼠作为乙型肝炎动物模型具的突出的价值。除人乙型肝炎病毒外,土拨鼠肝炎病毒(WHV)是唯一可整合入其宿主细胞DNA的趋肝病毒,并可形成慢性感染、肝细胞癌和Delta联合感染。这些特性为黑猩猩等所不及。目前迫切需要阐明的乙型肝炎慢性化和免疫耐受机理,整合病毒基因组在肝细胞癌发生过程中的作用,Delta联合感染和超感染的
Woodchucks as a prominent model of hepatitis B animal model. In addition to the human hepatitis B virus, the woodchuck hepatitis virus (WHV) is the only hepatitis virus that can be incorporated into the DNA of its host cells and can develop chronic infections, hepatocellular carcinoma and delta-associated infections. These features are beyond the reach of chimpanzees. There is an urgent need to elucidate the mechanism of chronic hepatitis B and immune tolerance, the role of integrating the genome of the virus in the development of hepatocellular carcinoma, Delta co-infection and superinfection