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目的:探讨乳腺癌组织中真核细胞起始因子4E(eIF4E)和Krüppel样因子4(KLF4)的表达及其临床意义。方法:收集广东医科大学附属医院2016年1月至2020年10月病理学确诊的73例乳腺癌组织和相应癌旁组织，使用免疫组织化学方法检测eIF4E蛋白和KLF4蛋白在组织中表达情况，结合临床资料采用n χ2检验。n 结果:乳腺癌组织组中eIF4E蛋白表达率高于相应癌旁组织组中eIF4E蛋白表达率[79.45%(58/73)比20.55%(15/73)，n χ2＝50.658，n P<0.01]，两者差异有统计学意义。eIF4E表达水平与乳腺癌肿瘤大小、组织学分级、TNM分期、淋巴结转移呈明显相关(n χ2＝4.842、9.230、7.103、5.560，n P<0.05)。乳腺癌组织组KLF4蛋白表达率高于相应癌旁组织组中eIF4E蛋白表达率[24.66%(18/73)比64.38%(47/73)，n χ2＝23.321，n P<0.01]，两者差异有统计学意义。KLF4表达水平与乳腺癌组织学分化程度、TNM分期、淋巴结转移呈明显相关[n χ2＝8.977、6.403、5.256，n P<0.05]。n 结论:eIF4E蛋白在乳腺癌组织中高表达、KLF4蛋白在乳腺癌组织中低表达，检测eIF4E和KLF4有助于判断乳腺癌的生物学行为和评估乳腺癌患者预后。“,”Objective:To explore the expression and clinical significance of eukaryotic initiation factor 4E (eIF4E) and Krüppel-like factor 4 (KLF4) in breast carcinoma tissues.Methods:The expression levels of eIF4E protein and KLF4 protein in 73 cases of human breast carcinoma tissues and non-cancerous adjacent breast tissues (5 cm distance away from the margin of breast carcinoma) of patients pathologically confirmed from January 2016 to October 2020 on Affiliated Hospital of Guangdong Medical University were examined by envision immunohistochemistry. The statistical analysis of Chi-square test in combination with clinical data were carried out.Results:The eIF4E protein expression rate in breast cancer tissues was significantly higher than that in the corresponding paracancerous tissues [79.45% (58/73) vs. 20.55% (15/73), n χ2=50.658, n P<0.01]. The eIF4E expression level was significantly correlated with breast cancer tumor size, histological grade, TNM stage. The eIF4E expression level was significantly correlated with tumor size, histological grade, TNM stage (tumor node metastasis stage), and lymph node metastasis (n χ2=4.842, 9.230, 7.103, 5.560, n P<0.05). KLF4 protein expression rate in breast cancer tissues was significantly higher than eIF4E protein expression rate in corresponding paraneoplastic tissues [24.66% (18/73) vs. 64.38% (47/73),n χ2=23.321, n P<0.01]. The KLF4 expression level was significantly correlated with histological differentiation degree, TNM stage, and lymph node metastasis of breast cancer (n χ2=8.977, 6.403, 5.256, n P<0.05).n Conclusion:This study suggested the high expression of eIF4E and low expression of KLF4 in breast carcinoma tissues. Detecting the expression levels of eIF4E and KLF4 might be help further understand the biological behavior of breast carcinoma and predict its prognosis.