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通过间接免疫荧光法和ELISA法对61例重症肌无力(MG)患者外周血淋巴细胞亚群、乙酰胆碱受体抗体(AchRab)进行检测,结果发现:重症肌无力者外周血中OKT_4~+、OKT_(11)~+细胞与正常对照组相比无明显变化,而OKT_8~+细胞较对照组降低,B细胞、OKT_4~+/OKT_8~+比值较对照组升高(P<0.01)。伴胸腺瘤或胸腺增生的MG患者,其OKT_4~+/OKT_8~+比值的变化与AchRab滴度呈线性相关。肾上腺皮质类固醇激素和胸腺摘除是治疗MG的重要手段,本组资料提示治疗后各免疫学参数有不同程度的改善,但以胸腺摘除法为佳。
The peripheral blood lymphocyte subsets and AchRab in 61 myasthenia gravis patients were detected by indirect immunofluorescence assay and ELISA. The results showed that OKT_4 ~ +, OKT_ (11) ~ + cells compared with the normal control group, while OKT_8 ~ + cells decreased compared with the control group. The ratio of OKT_4 ~ + / OKT_8 ~ + in B cells was higher than that in the control group (P <0.01). MG patients with thymoma or thymus hyperplasia, the OKT_4 ~ + / OKT_8 ~ + ratio changes and AchRab titer was linearly correlated. Adrenal corticosteroids and thymus removal is an important means of treatment of MG, the data suggest that the treatment of immunological parameters have varying degrees of improvement, but the thymus removal method is better.