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小白鼠单次口服朱砂的吸收半衰期为0.20h,消除半衰期为13.35h。口服朱砂后在动物的心、肾、肝、脾、肺、大脑、小脑等组织中均有不同程度的分布,而且随着服药次数的增加,组织中含汞量逐渐增大,其中尤以肾、肝突出。大剂量口服朱砂一个月的动物,其组织切片无明显病理变化,行为无异常。抗惊厥和脑、心电图变化实验表明,给药组产生惊厥时间平均可推迟1′20″,其脑电图频率减慢、波幅增大。朱砂含汞量为85.41%。
The single-use oral cinnabar had a half-life of absorption of 0.20 hours and an elimination half-life of 13.35 hours. After oral administration of cinnabar, there are different degrees of distribution in the heart, kidney, liver, spleen, lung, brain, cerebellum and other tissues of the animal, and as the number of medications increases, the amount of mercury in the tissues gradually increases, especially in the kidneys. Liver outstanding. Large doses of oral cinnabar one month animals, histological section no obvious pathological changes, no abnormal behavior. Anti-convulsions and changes in brain and electrocardiogram experiments showed that the convulsive time in the administration group was delayed by an average of 1′20′′, and the EEG frequency was reduced and the wave amplitude increased. The mercury content in the cinnabar was 85.41%.